Answer --- D -- Ste12
It's a protein factor found in nucleus in MAP kinase signaling of yeast . It's a sequence specific DNA binding transcription factor.
Which protein factor is found in the nucleus? (For MAPK signaling pathway -- yeast) Ste2 Ste5 Ste7 Ste12
Support the hypothesis that signaling pathways appeared early in evolution and are well-conserved using the yeast mating factor as an example. A) Signaling in yeast uses the RTK pathway and is evolutionarily conserved, like epinephrine signaling in humans. B) Signaling in yeast uses G-protein coupled receptors for signaling and is evolutionarily conserved, like epinephrine signaling in humans. C) Signaling in yeast uses an endocrine pathway and is evolutionarily conserved, like epinephrine signaling in humans. D) Mating factor in yeast uses...
A complex signaling pathway in yeast allows the cells to accumulate high concentrations of glycerol if they are exposed to high extracellular concentration of salt or glucose. The increased osmolarity of the extracellular medium activates Ras, which in turn activates adenylate cyclase. A second pathway, the HOG (high osmolarity glycerol) pathway activates the MAP kinase pathway. The target protein is the enzyme PFK2, which is activated by phosphorylation. (PFK2 produces an allosteric regulator that activates glycolysis, which ultimately produces glycerol.)...
Activity 4. Receptor signaling pathway A model of a G protein receptor signaling pathway is represented below. Activation of the signaling pathway results in a cell secreting a neurotransmitter through exocytosis. Activated - Activated adenylyl receptor cyclase GTP АТР CAMP Active G protein Protein- kinase A Inactive Active Protein targets Phosphate group A. Different steps in a signaling pathway can amplify the initial signal of one ligand binding to one receptor. Choose one step in the pathway below that results...
Which of the following is NOT an intracellular signaling protein activated by an RTK pathway? Akt Raf Erk adenylyl cyclase
Why do you think that ras is the most commonly deregulated protein in the RTK/ras/MAPK pathway?
What are the possible outcomes of phosphorylation of an effector protein in a signaling pathway?
Describe how a single protein in the tyrosine kinase signaling pathway possesses all the protein functions that characterize signal transduction.
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of these steps indicates the protein is activated after a GTP exchange step? B. (3pts) Which of these proteins can be deactivated by phosphatases? C. (4pts) Describe a mutation that would cause Ras to be permanently "on"? Would this mutation lead to high...
Problem Five One of the transducers in many growth factor signaling cascades is ras. a) How can mutations in ras (found in some types of cancers) contribute to transforming a normal cell into a tumor cell? b) Describe how ras plays a role in MAPK signaling pathways.
4) A signaling pathway proceeds through three protein kinases that are sequentially activated by phosphorylation. In one case, the kinases are held in a signaling complex by a scaffold protein. In the other, the kinases are freely diffusing. Discuss the properties of these two types of organization in terms of the signal amplification, speed, and potential cross talk between signaling pathways. (10 Points)