Solutions For An Introduction to Genetic Analysis Chapter 18 Problem 13P

631190-18-13P AID: 2498 | 24/12/2015

Cystic fibrosis (CF) is an autosomal recessive disorder. According to the given data the occurance of the cystic fibrosis (CF) as being 1/569 live births.

In Hardy-Weinberg equilibrium

p = frequency of the dominant allele in the population

q = frequency of the recessive allele in the population

2pq = frequency of heterozygous carriers in the population

Since the CF is recessive allele, the genotypic frequency q² = 1/569

Calculate the q

Calculate the p

Calculate the 2pq

Therefore, the estimated frequency of carriers of the disease allele in the Amish population is 0.08.