In a population, a locus has two alleles A and a. They have frequencies of p and q respectively. The relative genotypic fitnesses are shown in the table below:
Genotype | A/A | A/a | a/a |
Relative fitness | 1–s | 1 | 1–g |
In this population, we see the case of over dominance where heterozygotes have the highest fitness value of 1. Selection against the homozygous AA is s and against homozygous recessive aa is g.
a) If the mean fitness of allele A is equal to the fitness of allele a, then the equilibrium frequency of the allele would be:
The fitness can be calculated as:
b) When the value of s is 0.2 and g is 0.8:
Therefore, the value for p is 0.8.