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Solutions For An Introduction to Genetic Analysis Chapter 7 Problem 32P

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Solution 1

Telomeres are the linear, repetitive, noncoding (deoxyribonucleic acid) sequences, which acts as protective caps of eukaryotic liner chromosomes. They protect the chromosomes from degeneration by the (nonhomologous end joining) enzyme and exonucleases.

For example, Human telomeres have the repeat sequence. Telomerase (ribonucleoprotein) is an enzyme, which repair the lost telomeres after cell division and prevents shortening of the linear chromosome.

However, some species have variants of the telomere sequence . The most common variants of this sequence are , and . The first and second variants are usually present in the proximal areas of human telomeres.

These variants are generated due to over expression of the enzyme Telomerase, replication slippage or misincorporation of base pairs by telomerase, etc. However, these variants locate with great distance in the telomeres.

Therefore, this is reliable with an association concerning telomere lengthening by the enzyme telomerase and sequence-biased variant repeat generation in normal human cells. Hence, a species could exist with a combination of two different repeats on each of their telomeres.

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