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What would happen to a person who failed to make MHC receptor molecules? What are the...

What would happen to a person who failed to make MHC receptor molecules? What are the antigens and response that will be impacted?
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A person who failed to make MHC receptor molecule would not be able to activate the T cell-based immunity because of T-cell ( Th or Tc) require antigen presented over MHC molecule by antigen presenting cells to get activated and formed memory and effector cells. So, If MHC is not present then there will be no T- cell activation and adaptive immunity will be badly hampered.

Intracellular and extracellular antigen presentation will be affected which activates the cytotoxic T-cells and helper T-cell respectively.  So change in the MHC I will impact the Tc activation and response whereas MHC II will impact the Th cell response.

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