What two signaling molecules are generated by the hydrolysis of PIP4,5 and by what enzyme? What...
What two signaling molecules are generated by the hydrolysis of PIP4,5 and by what enzyme? What do each of these signaling molecules do?
Homework Answers
Answer : This is one of the two principal signal transduction pathways involving the G protein-coupled receptors.
The two signaling moecules are generated by the hydrolysis of Phosphatidyl inositol -4,5 bisphosphate (PIP4,5) generates two second messenegers, a water soluble product IP3 (inosito 1,4,5 triphosphate) and Diacylglycerol, a hydophobic product.
This is catalysed by an enzyme called by Phopsholipase C - beta
Diacylglycerol (DAG) which results from the braekdown of PIP2 binds to and actvates protein kinase C. This PKc phosphorylates serine/threonine residues of many substrate proteins which in turn elicits a number of cellular responses.
IP3 (inosito 1,4,5 triphosphate) binds to receptors on the sarcoplasmic reticulum resulting in the release of calcium.
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