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What is the mechanism of the disease, emphysema? What is the primary cause? Explain why people...

What is the mechanism of the disease, emphysema? What is the primary cause? Explain why people with this disorder have difficulty breathing properly and performing adequate gas exchange.

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the primary cause of emphysema is cigaratte smoking, air pollution .

cigarette smoking activates air epithelium and macrophages, which recruit neutrophills and CD8 + lymphocytes to cause emphysema . the oxidative stress caused by cigarette smoking activates different transcription factors and cytokines which in result to alveolar destruction . due to alveolar destruction exchange of gases could not take place in alveoli sacs, thus shortness of breath happens.

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