The reaction of an enzyme E with a substrate S typically passes through at least two inter...

The reaction of an enzyme E with a substrate S typically passes through at least two intermediates, ES and EP, and three transition states before reaching the dissociated product P:

From the data given above, prepare a diagram of the energy of reaction of fumarate to malate catalyzed by the enzyme fumarase as a function of the reaction coordinate. (See figure for an example of a simpler reaction.) Carefully label all enthalpy or energy differences for which you have information.

FIGURE Role of catalase in lowering the activation energy for the decomposition of H2O2.