Question

Write the equation for determining the glomerular filtration rate.

Answer 1

Equation used for calculation of eGFR is MDRD equation.= 186×(creatinine/88.4)power-1.154

×(age)power -0.203

×0.742 if female

×1.210 if black.

but this method is not accurate always so lab methods should be followed.

GFR is the glomerular filtration rate that is how much blood is filtered through glomerulus in one minute. This is equivalent to clearance value that is volume of plasma is cleared off a substance in one minute.

Substance to be considered should neither be reabsorbed nor secreted in the tubules of nephron,only filtered,eg- inulin,creatinine.

Formula used is C=U×V/P

here C = clearance=GFR, U= concentration of substance in urine, V= volume of urine excreated.

P= concentration of substance in plasma.

Though inulin is ideal choice, creatinine is used the most becoz it is produced inside body and no external source required.

Thus creatinine level in plasma and urine are important value in determination of renal function.