Hundreds of mutations in the enzyme glucose-6 phosphatase have been discovered. Why would this impact enzyme...
Hundreds of mutations in the enzyme glucose-6 phosphatase have been discovered. Why would this impact enzyme function?
Homework Answers
Mutation is the hereditary change in genetic material. In mutation these is changes in the gene code for glucose 6 phosphatase. As gene convert in to mRNA and protein by the process of transcription and translation respectively. Protein is the actual functional enzyme. In case of mutation in DNA , synthsized mRNA will have different codons and ultimately protein with different amino acid will be synthesized. As each protein has specific type of amino acid sequence and specific structural configuration to carry out specific function. Thus mutation can change amino acid sequence and also specific structure of that protein. Which ultimately alter the function of that protein.
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Hundreds of mutations in the enzyme glucose-6 phosphatase have
been discovered. Why would this impact enzyme...
How would you describe the polarity of the enzyme glucose-6-phosphatase, knowing it is a transmembrane protein?
How would you describe the polarity of the enzyme glucose-6-phosphatase, knowing it is a transmembrane protein?
7,9,11 please Free glucose Glucose-6-phosphatase Pucho s -6-phosphate Glycogen in o s--one Galacs 6. Why do...
7,9,11 please
Free glucose Glucose-6-phosphatase Pucho s -6-phosphate Glycogen in o s--one Galacs 6. Why do patients with GSD exhibit hepatomegaly? 7. Hundreds of mutations in the name glucose-6-phosphatase have been discovered most reult in small amore in mnace sequence. Based on your introductory exposure to protein structure, explain why this would impact the entryme's function & What kind of bond do you think is broken to digest cornstarch (be specific 9. In the comstarch therapy, what is the solvent...
a) The enzyme glucose 6-phosphatase is essential for the creation of glucose (which passes from the...
a) The enzyme glucose 6-phosphatase is essential for the creation of glucose (which passes from the liver to the blood stream) from pyruvate/glycogen? Choose the right option: pyruvate or glycogen b) Red blood cells lack mitochondria and thus they reduce Pyruvate to Lactate under aerobic/anaerobic conditions. Choose the right option: aerobic or anaerobic c) All enzymes involved in glycolysis are cytosolic. Correct or incorrect? d) The Mg+2 ion is a cofactor of most enzymes that participate in the process of...
During gluconeogenesis, why would the cell want to have the function of the fructose-6- bisphosphate phosphatase...
During gluconeogenesis, why would the cell want to have the function of the fructose-6- bisphosphate phosphatase be negatively regulated by high levels of AMP?
Hundreds of hemoglobin mutations have been described that result from a single amino acid change ...
Hundreds of hemoglobin mutations have been described that result from a single amino acid change in the primary sequence of the globin chains. Predict the effects on the following mutations on hemoglobin’s structural stability and function (ability to bind/release oxygen, bind allosteric effectors, etc, as appropriate): a] β-H87Y (hint: H87 in β-globin chain is equivalent to H64 in Mb) b] β-F42R (hint: F42 in β-globin chain is equivalent to F43 in Mb) c] β-K82E (hint: K82 is located in the...
The first enzyme in the pentose phosphate pathway that oxidize glucose glucose-6-phosophate to 6- phosphoglucono-6-lactone is...
The first enzyme in the pentose phosphate pathway that oxidize glucose glucose-6-phosophate to 6- phosphoglucono-6-lactone is glucose-6-phosophate dehydrogenase. Deficiency of this enzyme causes health issues. Write 2-1 page description on the deficiency of the enzyme due to genetic mutations. (if this enzyme activity has completely diminished due to mutation, we cannot live). Include these terms in your writing and underline them whenever you use the terms. Red blood cells, hemolytic anemia, fava beans, malaria, malaria drugs glutathione, NADPH
Question 2: You have just discovered a new enzyme that catalyzes the degradation of cellulose to glucose. You hope to commercialize this enzyme ultimately to invent a process for biofuel manufact...
Question 2: You have just discovered a new enzyme that catalyzes the degradation of cellulose to glucose. You hope to commercialize this enzyme ultimately to invent a process for biofuel manufacture. In order to determine how efficient the enzyme is and how fast the enzyme catalyzes the reaction, you have to perform some basic enzyme kinetics. Plot the following enzyme data for the enzyme catalyzed reaction and determine the Km and Vmax. Show your graph with correct units on the...
Von Gierke disease is frequently the result of a defect in glucose 6-phosphatase. Suggest another mutation...
Von Gierke disease is frequently the result of a defect in glucose 6-phosphatase. Suggest another mutation in glycogen metabolism that could cause symptoms like those of von Gierke disease. Explain why the two mutants would likely share symptom profiles.
Write a one sentence explanation for the following statement: The presence in liver of glucose-6-phosphatase is...
Write a one sentence explanation for the following statement: The presence in liver of glucose-6-phosphatase is essential to the function of the liver in synthesizing glucose for use by other tissues. a. Glucose-6-phosphate must be hydrolyzed in order for glucose to exit the liver cell and be exported to other tissues. b. Glucose-6-phosphate must be fully ucleaved in order for glucose to exit the liver cell and be exported to other tissues. c. Glucose-6-phosphate must lower the energy barier of...
2. Individuals lacking liver glucose-6-phosphatase accumulate a large amount of glycogen in the liver, while their...
2. Individuals lacking liver glucose-6-phosphatase accumulate a large amount of glycogen in the liver, while their blood glucose levels are only slightly increased when administered high doses of glucagon. What is the metabolic source of the glucose that causes the blood glucose levels to rise slightly? Justify your answer with key metabolic information regarding how glucagon affects cells, how the mutation changes cellular function, and how the glucose exits the cell.
7,9,11 please
Free glucose Glucose-6-phosphatase Pucho s -6-phosphate Glycogen in o s--one Galacs 6. Why do patients with GSD exhibit hepatomegaly? 7. Hundreds of mutations in the name glucose-6-phosphatase have been discovered most reult in small amore in mnace sequence. Based on your introductory exposure to protein structure, explain why this would impact the entryme's function & What kind of bond do you think is broken to digest cornstarch (be specific 9. In the comstarch therapy, what is the solvent...
The first enzyme in the pentose phosphate pathway that oxidize glucose glucose-6-phosophate to 6- phosphoglucono-6-lactone is glucose-6-phosophate dehydrogenase. Deficiency of this enzyme causes health issues. Write 2-1 page description on the deficiency of the enzyme due to genetic mutations. (if this enzyme activity has completely diminished due to mutation, we cannot live). Include these terms in your writing and underline them whenever you use the terms. Red blood cells, hemolytic anemia, fava beans, malaria, malaria drugs glutathione, NADPH
Question 2: You have just discovered a new enzyme that catalyzes the degradation of cellulose to glucose. You hope to commercialize this enzyme ultimately to invent a process for biofuel manufacture. In order to determine how efficient the enzyme is and how fast the enzyme catalyzes the reaction, you have to perform some basic enzyme kinetics. Plot the following enzyme data for the enzyme catalyzed reaction and determine the Km and Vmax. Show your graph with correct units on the...
2. Individuals lacking liver glucose-6-phosphatase accumulate a large amount of glycogen in the liver, while their blood glucose levels are only slightly increased when administered high doses of glucagon. What is the metabolic source of the glucose that causes the blood glucose levels to rise slightly? Justify your answer with key metabolic information regarding how glucagon affects cells, how the mutation changes cellular function, and how the glucose exits the cell.
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