Question

Adrenaline( also known as epinephrine). one of its effect is in the liver and in muscles to promote glycogenesis

0/2 pts Adrenaline (also known as epinephrine) is a hydrophilic hormone. One of its effects is in the liver and in muscles to promote glycogenesis (breaking glycogen into glucose). As a result, glucose levels rise in the blood within seconds. Adrenaline works by activating receptors which then lead to the enzyme that breaks down glycogen into glucose. intracellular receptors, transcription of the gene that codes for esinetrat codes tor face receator transcription of the cene that codes for

Answer 1

D.) Epinephrine stimulates glycogen breakdown in muscle and, to a lesser extent, in the liver.

1.The signal molecules epinephrine binds to receptors in the plasma membranes of muscle and liver cells. Epinephrine binds to the β-adrenergic receptor in muscle, and in liver it binds to α-adrenergic receptors in addition to β- adrenergic receptors. These binding events activate the α subunit of the heteromeric Gs protein. A specific external signal has been transmitted into the cell through structural changes, first in the receptor and then in the G protein.

2.The GTP-bound form of the α subunit of Gs activates adenylate cyclase, a transmembrane protein that catalyzes the formation of the secondary messenger cyclic AMP from ATP.

3.The elevated cytosolic level of cyclic AMP activates protein kinase A through the binding of cyclic AMP to the regulatory subunits, which then dissociate from the catalytic subunits. The free catalytic subunits are now active.

4.Protein kinase A phosphorylates the β subunit of phosphorylase kinase, which subsequently activates glycogen phosphorylase.

5. Glycogen phosphorylase leads to the glycogen breakdown into glucose units.