In this context, normal cell posses levels of telomerase below the levels required in order to maintain the telomere extension. In this way, the telomeres will be shortened in each cell division cycle. However, in the case of cancer, some specific genes are mutated and the cell will produce much more telomerases, increasing the telomere maintenance.
why are healthy ( non-cancerous) cells incapable of extending telomeres(
Suppose that a human zygote begins life with 1500 telomere repeats. Most somatic cells lose telomeres at every mitotic cell division. Further suppose that a cell begins to lose essential genes (non-telomere sequences) from its ends after 50 cell generations.How many cells are produced from one precursor cell after 50 cell generations, assuming that all cells survive? On average, how many telomeres are lost at each mitosis? Explain why telomeres are lost in the context of the question.
A) What are telomeres? B) Are telomeres present in both Prokaryotes and Eukaryotes? C) Explain why some cells have telomeres and others don't (base your explanation on the structure of the DNA molecule and the directionality of polymerases).
why mutants incapable of producing exotoxins are relatively easy to isolate compared to mutants incapable of producing endotoxins?
How does the boyden assay tets for cancerous cells compared to normal cells?
1. Explain why the replication machinery is incapable of completely replicating the ends of the chromosomes (4pt) What is the practical effect of this (4pt)? How do eukaryotic cells get around this problem (4pt)?
CTLs can kill cells infected with viruses or intracellular bacteria. They also can kill cancerous cells. How might an infected or cancerous cell evade immune control by CTLs? Increased expression of MHC class II molecules. Increased expression of MHC class I molecules. Decreased expression of MHC class I molecules.
Many adult tissues contain terminally differentiated cells that are incapable of proliferation. How can these tissues repair damage?
Give information on the difference between cancerous and healthy tissue. Discuss under what circumstances lasers can be used to differentially destroy tumors.
3. Cancerous tissue is composed of cells undergoing uncontrolled, rapid cell division. How could you develop a procedure to identify cancerous tissue by counting the number of cells undergoing mitosis?
List 5 abnormalities that you observed after researching karyotypes of cancerous cells.