Question

PLEASE HELP WITH THIS MICROBIOLOGY Q ASAP THANK YOU -

BASED ON HEPATITIS B VIRUS :

- What types of cells does it infect?
• What receptors does it attach to on host cells?
• How does the virus attach to host cells? Ie) are the proteins or glycoproteins on the virus that are used to attach to host cells identified?

PLEASE MAKE IT POINT FORM WITH REFERENCES TO SUPPORT THANK YOU.

Answer 1

BASED ON HEPATITIS B VIRUS :

• What types of cells does it infect?

-> It infectes liver cells (hepatocytes ).

www.healthonnet.org › Hepatitis › HBV_Chap1-3

• What receptors does it attach to on host cells?

  ->Virus attach to its host receptor, sodium taurocholate cotransporting polypeptide (NTCP).

www.pnas.org › content

• How does the virus attach to host cells ?

->Internalization of the viruses into host cells occurs through endocytosis.

-> HBV particles attach to host hepatocytes through cell-surface factors, heparan sulfate proteoglycans (HSPGs) with low affinity.

www.ncbi.nlm.nih.gov › pmc › articles › PMC4526719

• Are the proteins or glycoproteins on the virus that are used to attach to host cells identified ?

->  Yes , glycoproteins on surface of virus are used to attach to host cells identified.

-> These are small proteins namely LHBs, MHBs and SHBs.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574591/

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