Question

How do DNA sequences change protein structure and what are some affects to the protein

structures that can have an effect on the PTC receptor?

Answer 1

The protein sequence is determined by the DNA of the gene that can encode the protein. A change in the DNA gene sequence might lead to a change in the series of amino acids of the protein.

PTC tasting, is also called as phenylthiocarbamide tasting. It is a controlled genetically to taste phenylthiocarbamide and a number of similar substances, that have some activity of antithyroid.

The shape of the protein receptor determines how tightly it is bound to phenylthiocarbamide (PTC). All persons have two copies of every gene that are having the combinations of the bitter taste gene variants, which can determine whether someone finds PTC somewhat bitter, intensely bitter, or without taste at all.

The degree that shows differences in the phenylthiocarbamide receptor might affect the other tastes.

Computational tools are used to generate models of the receptor bound to phenylthiocarbamide (PTC) ligand to estimate binding sites and binding energies. In these models, phenylthiocarbamide (PTC) binds at a distant site from the amino acids (variants), and PTC binding energy that was equal for both the nontaster and taster forms of the protein. This models says that the inability of humans to taste phenylthiocarbamide (PTC) is due to a failure of G-protein activation rather than the decreased binding affinity of the receptor for PTC.