Incorrectly spliced RNAs often lead to human pathologies. Scientists have examined human cancer cells for splice-specific changes and found that many of the changes disrupt tumor-suppressor gene function (Xu and Lee, 2003. Nucl. Acids Res. 31: 5635–5643). In general, what would be the effects of splicing changes on these RNAs and the function of tumor-suppressor gene function? How might loss of splicing specificity be associated with cancer?
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