Cancer cells often have abnormal patterns of chromatin modifications. In some cancers, the DNA repair genes MLH1 and BRCA1 are hypermethylated on their promoter regions. Explain how this abnormal methylation pattern could contribute to cancer.
¦ HINT: This problem involves an understanding of the types of genes that are mutated in cancer cells. The key to its solution is to consider how methylation affects gene expression of cancer-related genes.
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