How many Ebola virus drugs have been approved for treatment by the US FDA? (1)
Imatinib (Gleevec or Glivec)
Nilotinib (Tasigna)
Miglustat
Clomiphene (Androxal, Clomid or Omifin)
Toremifene (Fareston or Acapodene)
Amiodarone (Cordarone, or Nexterone),
Dronedarone (Multaq) or Verapamil (Calan or Isoptin)
Amiloride (Midamor)
How many Ebola virus drugs have been approved for treatment by the US FDA? (1)
1. Remdesivir is an antiviral drug that was developed as a treatment for the Ebola virus and the Marburg virus. It is currently in clinical trials as a treatment for COVID-19. NH2 LON HOOH remdesivir The following questions are about the boxed portion of remdesivir, drawn below as its own molecule. a) Fill in the boxes about the hybridization and orbitals of this heterocycle. What is the hybridization of this N? o What orbital does this lone pair occupy? What...
Topic is treatment options for Ebola victims. The drugs under development need to be tested on a large scale with humans and many have not yet been tested on humans. Should we offer these experimental drugs to the countries in West Africa with large outbreaks for use in their populations as part of the drug trials we need to find effective treatment? Pro view? Con view?
Question2 (A) The US Federal Drugs Administration (FDA) recently approved a drug for a rare fatal genetic disease that had only been trialled on 12 patients, without a placebo. One condition of the approval is that the company must carry out a more complete trial, even though sufferers can receive the drug because it is approved. Why will it be difficult to carry out such a trial? (B) A recent study reported that upper class people spent less time than...
Hydroxychloroquine is one of several drugs being tested by the FDA as a possible treatment for COVID-19. Hydroxychloroquine is used for malaria and rheumatoid arthritis with two mechanisms. One is it blocks the virus. And the second is it tempers down inflammation, both of which play a role probably in how it's benefiting patients with COVID-19.(Dr. Agus) The drug molecule structure is given below. There are three different types of nitrogen in the molecule labeled as 1,2,3. Questions: 1) Based...
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The public's reaction to the threat of Ebola virus mirrored that of the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) epidemic when it first surfaced. Similar to Ebola virus, there were no effective management options when HIV first emerged, and both diseases had poor prognoses. Because healthcare facilities provide care to patients during any epidemic, healthcare workers (HCWs) are at increased risk of contracting infection, and not all HCWs have willingly accepted that obligation. In...
One of the first drugs to be approved for use in treatment
ofacquired immune deficiency syndrome (AIDS) is azidothymidine
(AZT).Complete the Lewis structure for AZT.
(a) How many carbon atoms are
sp3hybridized?
atoms
(b) How many carbon atoms are
sp2hybridized?
atoms
(c) Which atom is sp hybridized?
the O in the H-O-C group attached to
thefive-membered ring
center N in the N=N=N group
all the atoms
all Ns in the N=N=N group
the double bonded Cs
(d) How many σ...
A very popular drug in the treatment of the herpes simplex virus (HSV-1) is called acyclovir. When it comes to the treatment of HIV, the virus that causes AIDS, the most popular drug of choice is AZT (Retrovir). Explain why these drugs are called nucleoside analogues and which nucleotides these are analogues of? (0.5 pt.) Hypothesize how each of these drugs might be affecting the DNA replication of the viruses they are meant to target. Use a drawing to aid...
nce of serious symptoms is longer for AIDS 27] A difference between AIDS and Ebola virus a) Only AIDS is acquired by exposure to bodily fluids b) Only Ebola is acquired by exposure to bodily fluids c) The time between infection and appearance of serious symptoms is onger d) The time between infection and a range of serious symptoms is loner for EDO 28) The first synthetie antibiotic was a) penicillin b) sulfonamide c) Salvarsan 606 d) Morphine 29) The...
2. The FDA approves drugs when the drug has a beneficial effect in a controlled experi- ment, based on a one-sided 5% level test with Ho the drug has no effect. A drug company has developed a new painkiller for chronic pains, although it is doubtful whether the new drug actually has any effect. The company conducts a double-blind ex periment with n = 298 randomly chosen chronic pain patients over a 6 months period. All patients receive the drug...
The US pharmaceutical industry spent $6.4 billion on advertising prescription drugs directly to consumers in 2016. Since 1962 these ads have been regulated by the Food and Drug Administration (FDA) to ensure that they are not false or misleading. The United States and New Zealand are the only two countries where direct-to-consumer (DTC) advertising of prescription drugs is legal. Why should prescription drugs be advertised directly to consumers? Write at least five reasons.