Question

What is the pathophysiology of “Guillain-barre syndrome (GBS)” in your own words?

Answer 1

Pathophysiology of Gullain - barre syndrome.

      * It is an autoimmune disorder which triggered by bacteria or viral infections.

            (eg; cytomegalovirus,mycoplasm pneumoniae.)

      * Immune system (cell mediate and humoral) begin to attack on pheripheral nerve

        myelin proteins which are substances that the speed the conduction of nerve impulses.

      * This autoimmune reacton result in acute,rapid segmental demyelinaton of pheripheral

         nerves and cranial nerves.

      * It result in produce ascending weakness with dyskinesia (inability to do voluntary movements)

         hyporeflexia and parasthesia (numbness).