Problem

Solutions For An Introduction to Genetic Analysis Chapter 4 Problem 40P

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Solution 1

Three different crosses of the organism Neurospora are analyzed on the basis of unordered tetrads seen. The results of the cross are tabulated:

Picture 2

a) The frequency of recombinants can be calculated using the following formula:

Where, NPD stands for non-parental ditypes

T stands for tetrad.

For cross 1:

For cross 2:

For cross 3:

b) The uncorrected map distance based on RF can be calculated using the formula:

Where, NPD stands for non-parental ditypes

T stands for tetrad.

Total is the sum of PD, NPD, and T.

For cross 1:

For cross 2:

For cross 3:

The uncorrected map distances are thus calculated.

c) The corrected map distances based on tetrad frequencies can be calculated using the formula:

Where, NPD stands for non-parental ditypes

T stands for tetrad.

Total is the sum of PD, NPD, and T.

For cross 1:

For cross 2:

For cross 3:

d) The corrected map distance based on the mapping function:

Where, e = the base of natural logarithms

m = the mean number of successes in a defined sample size.

For cross 1:

For cross 2:

For cross 3:

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