Solutions For An Introduction to Genetic Analysis Chapter 9 Problem 15P

The experimental test of the idea is as follows:

The change in single nucleotide affects the three nearby amino acid changes in the protein. The change in one and two amino acids likely be much unusual than the three changes, which are exactly the reverse of the mechanism in proteins.

For instance, if the first is AAA, then the next must be AAN, where N can be any base. This situates severe restrictions on which the amino acid could be neighbour to each other.